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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27581


    標題: Synthesis and characteristics of poly(methyl methacrylate-methacrylic acid-3,3-(trimethoxysilyl) propyl methacrylate) hollow latex particles and their application to drug carriers
    作者: Liu, Yu-Sheng
    Chu, Chun-Hsun
    Tsai, Chen-An
    Chen, Yi-Hsuan
    Lee, Chia-Fen
    貢獻者: 化妝品應用與管理系
    關鍵字: Composite
    Drug Carriers
    Soapless Emulsion Polymerization
    Morphology
    Hollow Latex Particles
    日期: 2012-09
    上傳時間: 2014-03-21 16:14:13 (UTC+8)
    出版者: Springer
    摘要: In this study, the hollow latex particle was synthesized by three processes. The first process was to synthesize the poly(methyl methacrylate-co-methacrylic acid) (poly(MMA-MAA)) copolymer latex particles by the method of soapless emulsion polymerization. Following the first process, the second process was to polymerize MMA, MAA, 3,3-(trimethoxysilyl) propyl methacrylate (MPS), and ethylene glycol dimethacrylate in the presence of poly(MMA-MAA) latex particles to form the linear poly(MMA-MAA)/crosslinking poly(MMA-MAA-MPS) core-shell latex particles. In the third process, the core-shell latex particles were heated in the presence of ammonia to form the poly(MMA-MAA-MPS) hollow latex particles. A sufficient heating time and high-heating temperature were necessary for the ammonia to dissolve the linear poly(MMA-MAA) core to form a perfect hollow structure. The crosslinking poly(MMA-MAA-MPS) shell was a barrier for the ammonia to diffuse into the latex particles so that the latex particle with the high-crosslinking shell showed an imperfect hollow structure. Besides, the hollow poly(MMA-MAA-MPS) latex particles reacted with ZnO nanoparticles, which were synthesized by a traditional sol-gel method, to form the polymer/inorganic poly(MMA-MAA-MPS)/ZnO composite hollow latex particles. With the increase of crosslinking degree would increase the amount of ZnO bonding. Moreover, the poly(MMA-MAA-MPS) hollow latex particles were used as carriers to load with the model drug, caffeine. The release of caffeine from poly(MMA-MAA-MPS) hollow latex particles was investigated.
    關聯: Polymer Bulletin, 69(6), 699-714
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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