Co-occurrence of Anemia, Marginal Vitamin B-6, and Folate Status and Depressive Symptoms in Older Adults

doi:10.1177/0891988712458365

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/27571

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27571

Title:	Co-occurrence of Anemia, Marginal Vitamin B-6, and Folate Status and Depressive Symptoms in Older Adults
Authors:	Pan, Wen-Harn Chang, Yi-Ping Yeh, Wen-Ting Guei, Yu-Shu Lin, Bi-Fong Wei, Ien-Lan Yang, Feili Lo Liaw, Yung-Po Chen, Kuan-Ju Chen, Wei J. Pan, Wen-Harn �
Contributors:	保健營養系
Keywords:	Nutrition And Health Survey In Taiwan (Nahsit) Sf-36 Anemia Folate Vitamin B Elderly
Date:	2012-09
Issue Date:	2014-03-21 16:13:52 (UTC+8)
Publisher:	Sage Publications Inc
Abstract:	Although nutrient deficiencies are thought to play roles in the development of depression, observational studies have yielded inconsistent results. This study aimed to investigate whether multiple marginal nutrient deficiencies are associated with symptoms of depression in community-dwelling older Taiwanese. Data from 1371 elderly adults recruited from the Elderly Nutrition and Health Survey in Taiwan was used in this study. Depressive symptom scores on depressed mood and emotions affecting daily life were derived from the Medical Outcomes Study Short Form-36 (SF-36). Hemoglobin, serum ferritin, plasma vitamins B-6, B-12, and folate concentration, and erythrocyte transketolase and glutathione reductase activation coefficients were measured. After adjusting for age, gender, cognitive function, physical activity, disease history, and medication in the multivariate analysis, anemia, and marginal B-6 deficiency were significantly associated with the presence of depression symptoms, respectively. In addition, co-occurrence of vitamin B-6 with low folate level and co-occurrence of anemia either with low vitamin B-6 or with folate level were all associated with the depressive mood and with depressive emotions defined by SF-36 (odds ratios [OR] in the range of 2.32-7.13, all P values acurrency <= 05). The magnitude of the ORs is larger when the number of deficiencies increased. Elderly people with coexisting marginal deficiencies of nutrients involved in the S-adenosylmethionine and hemoglobin production were more likely to experience depressed mood and emotion that affect daily activity. Examining status of these nutrients is worthy of consideration for older adults with depressed symptoms.
Relation:	Journal of Geriatric Psychiatry And Neurology, 25(3), 170-178
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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