Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin

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Title:	Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin
Authors:	Guo, Chun-Jun Knox, Benjamin P. Chiang, Yi-Ming Lo, Hsien-Chun Sanchez, James F. Lee, Kuan-Han Oakley, Berl R. Bruno, Kenneth S. Wang, Clay C.C.
Contributors:	藥學系
Keywords:	Aspergillus-Terreus 3,5-Dimethylorsellinate Metabolite Austin
Date:	2012-11-16
Issue Date:	2014-03-21 16:12:25 (UTC+8)
Publisher:	Amer Chemical Soc
Abstract:	Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.
Relation:	Organic Letters, 14(22), 5684-5687
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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