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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27526


    標題: Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin
    作者: Guo, Chun-Jun
    Knox, Benjamin P.
    Chiang, Yi-Ming
    Lo, Hsien-Chun
    Sanchez, James F.
    Lee, Kuan-Han
    Oakley, Berl R.
    Bruno, Kenneth S.
    Wang, Clay C.C.
    貢獻者: 藥學系
    關鍵字: Aspergillus-Terreus
    3,5-Dimethylorsellinate
    Metabolite
    Austin
    日期: 2012-11-16
    上傳時間: 2014-03-21 16:12:25 (UTC+8)
    出版者: Amer Chemical Soc
    摘要: Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.
    關聯: Organic Letters, 14(22), 5684-5687
    Appears in Collections:[藥學系(所)] 期刊論文

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