Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27072
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 17326/19632 (88%)
造访人次 : 3598274      在线人数 : 1153
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    標題: PEGylated Liposomes Incorporated with Nonionic Surfactants as an Apomorphine Delivery System Targeting the Brain: In Vitro Release and In Vivo Real-time Imaging
    作者: Hsu, Shu-Hui
    Saleh, A.Al-Suwayeh
    Chen, Chih-Chieh
    Chi, Chen-Hsien
    Fang, Jia-You
    貢獻者: 藥學系
    關鍵字: Apomorphine
    PEGylated liposomes
    blood-brain barrier
    brain targeting
    drug delivery systems
    Nonionic Surfactants
    Real-time Imaging
    Parkinson's disease
    日期: 2011-04
    上傳時間: 2013-10-25 15:33:48 (UTC+8)
    出版者: Bentham Science Publ Ltd
    摘要: The clinical application of apomorphine, a dopamine receptor agonist for treating Parkinsons disease, is limited by its instability and the need for frequent injections. In the present work, apomorphine was encapsulated within liposomes to protect it from degradation and enhance the permeability across the blood-brain barrier (BBB). Stearylamine was used to produce a positive surface charge for the liposomes. The liposomal systems with different compositions were characterized by the mean size, zeta potential, drug encapsulation percentage, stability, and in vitro release characteristics. PEGylated liposomes and liposomes incorporating Brij 78 showed a size of 130~160 nm. When Tween 80 was added to the liposomes, the vesicle size increased to > 260 nm. Apomorphine was successfully entrapped by liposomes with an encapsulation percentage of > 70%, with the systems containing Brij 78 showing the highest level of 99%. The loading of apomorphine into liposomes resulted in slower release behavior compared to the drug in an aqueous solution. In comparison to free drug, apomorphine in PEGylated liposomes exhibited greater stability in plasma. The in vivo brain uptake of PEGylated liposomes after an intravenous bolus injection into rats was monitored by in vivo real-time bioluminescence imaging for 1 h. The results showed that the uptake of PEGylated liposomes into the brain was rapid and prolonged. PEGylated liposomes may offer a promising strategy for targeting apomorphine to the brain. This opens up new opportunities for treating Parkinsons disease.
    關聯: Current Nanoscience, 7(2), pp.191-199
    显示于类别:[藥學系(所)] 期刊論文


    档案 描述 大小格式浏览次数

    在CNU IR中所有的数据项都受到原著作权保护.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈