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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27069


    標題: Characterization of quaternized chitosan-stabilized iron oxide nanoparticles as a novel potential magnetic resonance imaging contrast agent for cell tracking
    作者: Shen, Chia-Rui
    Wu, Shu-Ting
    Tsai, Zei-Tsan
    Wang, Jiun-Jie
    Yen, Tzu-Chen
    Tsai, Jin-Sheng
    Shihe, Mei-Fen
    Liu, Chao-Lin
    貢獻者: 藥學系
    關鍵字: cell tracking
    chitosan
    N-[(2-hydroxy-3-trimethylammonium)propyl] chitosan chloride (HTCC)
    magnetic resonance imaging (MRI)
    superparamagnetic iron oxide (SPIO)
    日期: 2011-06
    上傳時間: 2013-10-25 15:33:45 (UTC+8)
    出版者: Wiley-Blackwell
    摘要: Polymer-stabilized iron oxide nanoparticles could be used as contrast agents in magnetic resonance imaging (MRI) due to their unique superparamagnetism. Here we demonstrate a quaternized chitosan, i.e. N-[(2-hydroxy-3-trimethylammonium)propyl] chitosan chloride (HTCC), encapsulating superparamagnetic iron oxide (SPIO), with very low toxicity and less effect on cell growth. HTCC has quaternary amino groups introduced into the chitosan chain, and such modification of chitosan should render it soluble in water. Most importantly, the HTCC–SPIO thus prepared has the ability to accelerate the MRI relaxation processes of surrounding water protons, resulting in enhanced MRI contrast (R2: y = 0.1076x − 0.0092; R1: y = 0.008x − 0.0005). The iron content quantified by Prussian blue staining and MRI revealed a positive correlation between Prussian blue positive cells and the change of MRI signal intensity. Also, transmission electron microscopy and element mapping confirmed intracellular metal-like spots as internalized iron oxide. Such findings support the use of these quaternized chitosan-stabilized iron oxide nanoparticles as a potential MRI contrast agent for cell tracking. Copyright © 2011 Society of Chemical Industry
    Appears in Collections:[藥學系(所)] 期刊論文

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