English  |  正體中文  |  简体中文  |  Items with full text/Total items : 16959/19260 (88%)
Visitors : 7632009      Online Users : 48
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/26835


    標題: 探討丁基原啡因對嗎啡成癮大鼠之神經傳導物質含量的影響
    Study on the effect of buprenorphine on neurotransmitter levels in morphine dependence rat
    作者: 劉國盛
    陳素容
    陳郁文
    宋國峻
    王志中
    貢獻者: 嘉南藥理科技大學藥物科技研究所
    嘉南藥理科技大學藥學系
    中國醫藥大學物理治療學系
    奇美醫學中心醫學研究部
    關鍵字: 丁基原啡因
    嗎啡
    戒斷症候群
    神經傳導物質
    Buprenorphine
    Morphine
    Withdrawal symptoms
    Neurotransmitter
    日期: 2012-12
    上傳時間: 2013-08-14 10:42:21 (UTC+8)
    摘要: 長期使用嗎啡易產生耐受性及成癮性,當突然中斷或降低劑量時會出現戒斷症候群,目前已知戒斷症候群與神經傳導物質如多巴胺、血清素等有相關性。
    本研究以大鼠為研究對象,利用微透析管在腦中取樣,再使用高效能液相層析-電化學偵測器分析神經傳導物質含量變化,以探討丁基原啡因對成癮大鼠腦中神經傳導物質之影響。
    結果顯示,丁基原啡因可使DA、Dopac 及HVA 之含量,呈現微幅上升,NE 及5-HTP 之含量則有明顯上升趨勢,5-HIAA 則呈現微幅之下降,而EP 則有明顯下降趨勢,NM 則維持不變。丁基原啡因對成癮大鼠腦中神經傳導物質之影響和嗎啡類似,推測其減癮效果可能和morphin like effect 有關。
    Chronic treatment with morphine may induce tolerance and addiction. The withdrawal syndromes, which may result from the stop or dramatic reduction of morphine intake, are identified to be related to several neurotransmitters, such as dopamine and serotonin.
    In this study, high performance liquid chromatography-electrochemical detection (HPLC-ECD) was used after microdialysis sampling for the determination of the neurotransmitters in the rat corpus striatum. As a result, buprenorphine slightly increased the levels of DA, Dopac and HVA, while significantly increased the levels of NE and 5-HTP. In contrast, buprenorphine slightly decreased the levels of 5-HIAA but significantly lowered that of EP. It had no influence on NM. Buprenorphine-mediated effects were similar to that of morphine.
    In summary, the impact on reducing the withdrawal symptoms to buprenorphine action may be through similar effects regulated by morphine.
    Appears in Collections:[嘉南學報] 38 期 (2012)
    [藥學系(所)] 期刊論文

    Files in This Item:

    File SizeFormat
    38_68_74.pdf1009KbAdobe PDF971View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback