Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/26708
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    標題: Cardiovascular protection of deep-seawater drinking water in high-fat/cholesterol fed hamsters
    作者: Hsu, Chin-Lin
    Chang, Yuan-Yen
    Chiu, Chih-Hsien
    Yang, Kuo-Tai
    Wang, Yu
    Fu, Shih-Guei
    Chen, Yi-Chen
    貢獻者: 生活應用與保健系
    關鍵字: Deep seawater
    Cardiovascular protection
    LDL receptor
    CYP7A1
    Hamster
    Serum lipids
    Serum lipid peroxidation
    日期: 2011-08
    上傳時間: 2013-06-20 15:53:06 (UTC+8)
    出版者: Elsevier
    摘要: Cardiovascular protection of deep-seawater (DSW) drinking water was assessed using high-fat/cholesterol-fed hamsters in this study. All hamsters were fed a high-fat/cholesterol diet (12% fat/0.2% cholesterol), and drinking solutions were normal distiled water (NDW, hardness: 2.48 ppm), DSW300 (hardness: 324.5 ppm), DSW900 (hardness: 858.5 ppm), and DSW1500 (hardness: 1569.0 ppm), respectively. After a 6-week feeding period, body weight, heart rates, and blood pressures of hamsters were not influenced by DSW drinking waters. Serum total cholesterol (TC), triacylglycerol (TAG), atherogenic index, and malondialdehyde (MDA) levels were decreased (p < 0.05) in the DSW-drinking-water groups, as compared to those in the NDW group. Additionally, increased (p < 0.05) serum Trolox equivalent antioxidant capacity (TEAC), and faecal TC, TAG, and bile acid outputs were measured in the DSW-drinking-water groups. Hepatic low-density-lipoprotein receptor (LDL receptor) and cholesterol-7α-hydroxylase (CYP7A1) gene expressions were upregulated (p < 0.05) by DSW drinking waters. These results demonstrate that DSW drinking water benefits the attenuation of high-fat/cholesterol-diet-induced cardiovascular disorders in hamsters.
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