Antioxidant, antinociceptive, and anti-inflammatory activities of Xanthii Fructus extract

doi:10.1016/j.jep.2011.03.057

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/26685

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標題:	Antioxidant, antinociceptive, and anti-inflammatory activities of Xanthii Fructus extract
作者:	Huang, Ming-Hsing Wang, Bor-Sen Chiu, Chuan-Sung Amagaya, Sakae Hsieh, Wen-Tsong Huang, Shyh-Shyun Shie, Pei-Hsin Huang, Guan-Jhong
貢獻者:	化粧品應用與管理系食品科技系
關鍵字:	Chinese medicine Xanthii Fructus Antioxidant Antinociceptive Anti-inflammatory
日期:	2011-05
上傳時間:	2013-06-03 15:53:08 (UTC+8)
出版者:	Elsevier
摘要:	Ethnopharmacological relevance Xanthii seeds commonly called Cang-Erzi were used as a traditional Chinese medicine for treating sinusitis, headache due to rheumatism and skin pruritus. Aim of the study In order to evaluate the actions of this plant, studies were performed on antioxidant, antinociceptive, and anti-inflammatory activities. Materials and methods The aqueous extract of Xanthii Fructus (AXF) was evaluated in mice for anti-inflammatory activity using carrageenan-induced hind paw edema model. The antinociceptive activity of AXF was evaluated by writhing and formalin tests. Antioxidant properties were assayed in terms of antioxidant activity by scavenging abilities on 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid (ABTS), reducing activity and liposome protection. In addition, the total phenolic content was determined with spectrophotometric method. Results AXF exhibited significant radical scavenging and reducing activity. And oral treatment with AXF elicited inhibitory activity on acetic acid effect and reduced the formalin effect at the late-phase. In the anti-inflammatory test, AXF inhibited the development of paw edema induced by λ-carrageenan (Carr). AXF decreased the paw edema at the fifth hour after Carr administration, and increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the liver tissue and decreased the malondialdehyde (MDA) level in the edema paw. AXF decreased the level of serum nitric oxide (NO) and tumor necrosis factor (TNF)-α after Carr injection and AXF decreased the levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions in paw edema at the fifth hour. Conclusions AXF shows antioxidant, antinociceptive, and anti-inflammatory activities, supporting the folkloric usage of the plant to treat various inflammatory diseases.
關聯:	Journal of Ethnopharmacology 133(2), pp. 545-552
显示于类别:	[化妝品應用與管理系(所)] 期刊論文 [ 食品科技系 ] 期刊論文

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