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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/26684


    標題: Antioxidant and anti-inflammatory properties of Cardiospermum halicacabum and its reference compounds ex vivo and in vivo
    作者: Huang, Ming-Hsing
    Huang, Shyh-Shyun
    Wang, Bor-Sen
    Wu, Chieh-Hsi
    Sheu, Ming-Jyh
    Hou, Wen-Chi
    Lin, Shiang-Shiou
    Huang, Guan-Jhong
    貢獻者: 化粧品應用與管理系
    生活應用與保健系
    關鍵字: Cardiospermum halicacabum
    Chinese medicine
    Antioxidant
    Anti-inflammation
    NO
    TNF-α
    日期: 2011-01
    上傳時間: 2013-06-03 15:53:06 (UTC+8)
    出版者: Elsevier
    Elsevier
    Elsevier
    摘要: Aims of the study
    Cardiospermum halicacabum (CH) has been used in Chinese medicine for a long time. However, its fingerprint chromatogram, antioxidant, anti-inflammatory effects and mechanism are still needed to be explored. Therefore, the aims of this study investigated the antioxidant and anti-inflammatory effects of CH extracts and its reference compounds ex vivo and in vivo.

    Materials and methods
    In HPLC analysis, the fingerprint chromatogram of ethanolic extract of CH (ECH) was established. The effects of ACH (aqueous extract of CH) and ECH extracts were assessed for the antioxidant and LPS-induced NO production in RAW264.7 cells. In vivo anti-inflammatory activities of ECH were evaluated in mouse paw edema induced by λ-carrageenan (Carr). We investigate the anti-inflammatory mechanism of ECH via studies of the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the liver and the levels of malondialdehyde (MDA) and nitrite oxide (NO) in the edema paw. Serum NO and TNF-α were also measured.

    Results
    ECH had better antioxidant activity than that of ACH. In the anti-inflammatory test, ECH inhibited the development of paw edema induced by Carr and increased the activities of CAT, SOD and GPx in the liver tissue. ECH also decreased the level of NO in edematous paw tissue and in serum level, and diminished the level of serum TNF-α at the fifth hour after Carr injection.

    Conclusions
    ECH exerts anti-inflammatory effects by suppressing TNF-α and NO. The anti-inflammatory mechanism of ECH might be related to the decrement of the level of MDA in the edema paw via increasing the activities of CAT, SOD and GPx in the liver. The results showed that ECH might serve as a natural antioxidant and anti-inflammatory agent.
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文
    [生活應用與保健系] 期刊論文

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