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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/26672


    標題: Paraminabeolides A−F, Cytotoxic and Anti-inflammatory Marine Withanolides from the Soft Coral Paraminabea acronocephala
    作者: Chao, Chih-Hua
    Chou, Kuei-Ju
    Wen, Zhi-Hong
    Wang, Guey-Horng
    Wu, Yang-Chang
    Dai, Chang-Feng
    Sheu, Jyh-Horng
    貢獻者: 化粧品應用與管理系
    日期: 2011-01
    上傳時間: 2013-06-03 15:52:54 (UTC+8)
    摘要: Six new withanolides, paraminabeolides A−F (1−6), along with five known compounds, minabeolides-1, -2, -4, -5, and -8 (7−11), were isolated from a Formosan soft coral, Paraminabea acronocephala. The structures of these compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The absolute configuration of 4 was determined by the application of Mosher’s method. Compounds 1 and 7 were cytotoxic toward Hep G2 cancer cells. Compounds 1−4 and 7−10 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein. Compounds 7−10 also could effectively reduce the expression of COX-2 protein.
    關聯: Journal of Nature Products 74(5), pp. 1132-1141
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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