Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25965
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 18034/20233 (89%)
造访人次 : 23360810      在线人数 : 570
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/25965


    標題: The Rate of Elimination and Distribution Volume of Rabbit Muscle Creatine Phosphokinase
    作者: Hsingchu Hsu
    Jun Watanabe
    關鍵字: rabbit muscle creatine phosphokinase
    intravenous administration
    pharmacokinetic parameter
    endogeneous fluctuation
    日期: 1983
    上傳時間: 2012-11-16 09:01:53 (UTC+8)
    摘要: An in vivo study on the elimination of rabbit muscle creatine phosphokinase (CPK) following intravenous administration has been carried out with nine rabbits selected for low endogeneous CPK fluctuation character. A two-compartment open model is proposed for the disposition of CPK. The equation Cp= Ae -αt+ Be -βt was employed to fit the profile of CPK activity in the plasma. The pharmacokinetic parameters of CPK in rabbits were determined at low, medium and high dose levels, and the factors which affect the estimation of pharmacokinetic parameters are discussed. The elimination of CPK appeared to be independent of the injected dose, but the intersubject variability was significant. The pharmacokinetic parameters α and β at high injected dose (860 U/ kg body weight, n=9) were estimated to be 0.432 +- 0.274 h-1 and 0.099+-0.031 h-1. This value for β in vivo is significantly larger than the inactivation rate constant of CPK in vitro. Hence, there must be some other mechanism involved in vivo in addition to simple inactivation in the circulation by the body temperature. The distribution volume of injected CPK in the steady state was estimated to be approximately 4.3 +-1.1% of body weight. The result suggests that injected CPK is distributed into a major compartment (plasma) and a minor one (assumed to be interstitium).
    關聯: 嘉南學報 9, A14-A19
    轉載自 Chem. Pharm. Bull., 31(2), 626-631 (1983)
    显示于类别:[嘉南學報] 9 期 (1983)

    文件中的档案:

    没有与此文件相关的档案.



    在CNU IR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈