Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25964
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    標題: The Rate of Appearance and Disappearance of Plasma Muscle Creatine Phosphokinase in Rabbits after Intramuscular Administration of Sulpyrine Injection
    作者: Chao-Hsiung Wang
    Hanjong Pern
    Hsingchu Hsu
    日期: 1983
    上傳時間: 2012-11-16 09:01:50 (UTC+8)
    摘要: The appearance and disappearance profile of plasma CPK in rabbits after intramuscular administration of 25% (w/v) of sulpyrine injection was demonstrated with seven rabbits. The profiles in five rabbits showed a biphasic pattem and could be fitted to an one-compartment open model whereas the remainder showed an erratic pattern. The mean rate constant of appearance (Kap) and disappearance (Kap) of CPK after sulpyrine injection were estimated to be 0.14 +- 0.047 (mean +- S.D.) and 0.062 +- 0.015 h-1.The regression equations obtained by the weighted damping Gauss-Newton method were presented.By using the estimation of 95% confidence intervals, Kap can be derived from the sum of Kdp and β (overall elimination rate constant from in bolus experiment).The result provides an approximate estimation for the Kap in the case ot erratic profile.
    關聯: 嘉南學報 9, A1-A7
    轉載自 臺灣藥學雜誌, 34(2)
    显示于类别:[嘉南學報] 9 期 (1983)



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