Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25955
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    CNU IR > Chna Nan Annual Bulletin > Vol.9 (1983) >  Item 310902800/25955
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/25955


    Title: New Dimeric Analogs of 2-Aminodipyrido[L,2-A:3 ,2,-D] Imidazole : Synthesis And Interaction With DNA
    Authors: Ching-Shing Lee
    Yuichi Hashimoto
    Toshiharu Ohta
    Koichi Shudo
    Toshihiko Okamoto
    Keywords: intercalation
    2-aminodipyrido〔1,2-a:3,2-d〕imidazole
    DNA
    melting temperature of DNA
    dimeric intercalator
    Date: 1983
    Issue Date: 2012-11-16 09:01:27 (UTC+8)
    Abstract: New dimeric analogs of intercalative 2-aminodipyrido - [1,2-a:3 ,2-d]imidazole (Glu-P-2), a potent muta-carcinogen isolated from a pyrolysate of L-glutamic acid, were synthesized. The high affinity of these compounds to DNA was demonstrated by fluorescence spectroscopic studies and by their effects in raising the melting temperature (TM) of DNA.
    Relation: 嘉南學報 9, A37-A40
    轉載自 Chem. Pharm. Bull. ,30(8),3046-3049
    Appears in Collections:[Chna Nan Annual Bulletin] Vol.9 (1983)

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