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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/25507


    標題: BROMOPAVINE與PHENOLIC MONOPAVINE的合成研究
    Synthetic Studies on Bromopavine and Phenolic Monopavine
    作者: 莊世憲
    貢獻者: 藥學科
    日期: 1984
    上傳時間: 2012-09-12 16:29:22 (UTC+8)
    摘要: 為提供合成各種Bispavine類衍生物,乃從事Bromopavine及Phenolic monopavines之合成研究。分別以3-Hydr oxybenzalde hyde及Vanillin為起始物,經數步反應形成Phenylethylamines之衍生物(Ⅶa,b,c)然後將此Ⅶa及VIIc與3,4-Dimethoxyphenyl acetic acid (VIIIa ), VIIb及VIIc與m-Methoxyphenyl acetic acid (Ⅷ b)縮合成醯胺類衍生物(Ⅸa,b,c,d),經Bischler - Napieralski環化反應,得異喹啉衍生物( Xa,b,c,d )。將其製成N一甲基碘鹽( XIa,b,c,d )後,經部分還原得N一甲基一l, 2一二氫基異喹啉(Ⅶa,b,c,d),然後在酸催化下,XIIa,b 環化成2, 8, 9-Trimethoxy-N-methylpavinane ( Ia ), XIIc,d環化成二個Phenolic monopavines 2, 8 - Dimethoxy-9-hydroxypavinane( Ib )及(±) -Norargemonine ( Ic )。再將Pavine Ia進行溴化反應,得到Mono-bromopavineⅡa。此溴化反應具有Regiospecific之特性,溴取代在苯環C-1的位置。日後之研究,可試將Monobromopavine II與Phenolic monopavines ( Ib及Ic )以Ullmann condensation結合成二種Bispavines.或試將二個Phenolic monopavines ( Ib及Ic )溴化為Monobromophenolic pavine,再與Ib及Ic進行Ullmann condensation結合成各種Bispavines,以提供各種Pavines雙聚合體之物理、化學、生物活住之研究。
    關聯: 嘉南學報 10期 : p.31-46
    Appears in Collections:[嘉南學報] 10期 (1984)
    [藥學系(所)] 期刊論文

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