Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/2542
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    Title: 炸油或藥物投與對維生素E代謝途徑之探討
    Vitamin-E Supplementation Restored Hepatic Vitamin-E Levels but not Protein Levels of Antioxidant Enzymes Decreased by Administration of Pregnenolone-16-Carbonitrile in Rats
    Authors: 蕭慧美;HUEY-MEI SHAW
    Contributors: 保健營養系
    Keywords: α-tocopherol
    TBARS
    antioxidant enzyme
    cytochrome P450
    rat
    Date: 2007
    Issue Date: 2008-07-31 16:50:52 (UTC+8)
    Publisher: 台南縣:嘉南藥理科技大學保健營養系
    Abstract: Pregnenolone-16-carbonitrile (PCN) is a synthetic steroid and an
    inducer of the cytochrome P450 3A gene in rats. The aim of this study was to evaluate
    the effects of PCN administration on vitamin-E status and antioxidant enzyme protein
    levels in rats fed a vitamin-E supplemented diet. Two groups of Wistar rats were fed
    for three weeks with a basal diet (containing 50 ppm of -tocopherol) or the same diet containing tenfold more -tocopherol. In the last three days, each group was divided
    into two subgroups which were given a single intraperitoneal injection of PCN at 75
    mg/kg/day (P50 and P500 groups) or DMSO (C50 and C500 groups). PCN
    significantly reduced -tocopherol contents in the liver and plasma. Tenfold
    supplementation of -tocopherol (P500 group) could return liver -tocopherol levels to that of the C50 group. The TBARS concentration was significantly elevated by
    PCN administration in the liver and lung by Two-way ANOVA analysis. PCN showed
    a significant reduction in the protein levels of catalase and glutathione peroxidase (GPx). Dietary vitamin-E supplementation altered the protein levels of GPx and
    superoxide dismutase, but not catalase. Vitamin-E supplementation protected against
    PCN-induced lipid peroxidation and compromized vitamin-E status by CYP3A
    induction and antioxidant enzyme reduction. The mechanism of this protection
    appears to be due to scavenging the reactive metabolite by vitamin-E rather than increasing antioxidant enzyme levels.
    Appears in Collections:[Dept. of Health and Nutrition (including master's program)] NSC Project

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