Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25387
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    標題: Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans
    作者: James F. Sanchez
    Yi-Ming Chiang
    Edyta Szewczyk
    Ashley D. Davidson
    Manmeet Ahuja
    C. Elizabeth Oakley
    Jin Woo Bok
    Nancy Keller
    Berl R. Oakley
    Clay C. C. Wang
    貢獻者: 藥物科技研究所
    日期: 2010-03
    上傳時間: 2012-06-04 16:40:14 (UTC+8)
    出版者: Royal Soc Chemistry
    摘要: F-9775A and F-9775B are cathepsin K inhibitors that arise from a chromatin remodelling deletant strain of Aspergillus nidulans. A polyketide synthase gene has been determined to be responsible for their formation and for the simpler, archetypical polyketide orsellinic acid. We have discovered simple culture conditions that result in the production of the three compounds, and this facilitates analysis of the genes responsible for their synthesis. We have now analysed the F9775/orsellinic acid gene cluster using a set of targeted deletions. We find that the polyketide synthase alone is required for orsellinic acid biosynthesis and only two additional genes in the cluster are required for F9775 A and B synthesis. Our deletions also yielded the bioactive metabolites gerfelin and diorcinol.
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