Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25273
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 18034/20233 (89%)
造访人次 : 23596768      在线人数 : 713
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/25273


    標題: Percutaneous absorption of piroxicam from ointment bases in rabbits
    作者: Yi-Hung Tsai
    Li-Ren Hsu
    Shun-Ichi Natio
    貢獻者: 藥學科
    日期: 1985
    上傳時間: 2012-05-24 11:00:44 (UTC+8)
    摘要: In order to investigate the process of percutaneous absorption from various ointment bases, the blood levels of piroxicam were determined at optimal intervals after the ointment application in rabbtts. After the oral and intravenous administrations, the plasma levels of piroxicam were described by the two-compartment model. A pharmacokinetic model similar to the percutaneous absorption of indomethacin was developed to test the concepts regarding the percutaneous absorption of piroxicam from topical ointment bases. A reasonably good fit between experimental and calculated values was obtained by taking into account identical absorption rate constant (Ka) and the changes in drug release constant (Kr) and the fraction of drug absorbed (F). We found that piroxicam in the o/w ointment base (UCH ointment containing12% propylene glycol) had a better percutaneous absorption effect than the other three different kinds of ointment bases which were a simple ointment, PEG ointment and petrolatum rosewater Ointment.The pH value of the water phase in UCH ointment containing 12% propylene glycol was adjusted to pH 9.2 by the sodium bicarbonate-buffered solution, then the percutaneous absorption of piroxicam could be increased. The effect of the amount of Piroxicam on the percutaneous absorption was also investigated.The optimal effect with the additives in the ointment was finally attained with an addition of 5% urea.
    關聯: 嘉南學報 11期：p.A1-A18 轉載 International journal of pharmaceutics 24(1985) p.61-78
    显示于类别:[嘉南學報] 11期 (1985)
    [藥學系(所)] 期刊論文

    文件中的档案:

    没有与此文件相关的档案.



    在CNU IR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈