Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25226
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    標題: Upregulation of lipogenesis and protein tyrosine phosphatase-1B expression in the liver of wistar rats with metabolic syndrome chronically induced by drinking sucrose water
    作者: Chun-Yin Huang
    Yu-Shun Lin
    Gou-Chun Chen
    Hui-Ling Huang
    Shu-Han Chuang
    Pei-Min Chao
    貢獻者: 保健營養系
    關鍵字: Metabolic syndrome
    Sucrose-containing drinking water
    Sterol regulatory element-binding protein-1c
    Carbohydrate response element-binding protein
    Protein tyrosine phosphatase-1B
    日期: 2010-11
    上傳時間: 2012-05-21 16:30:04 (UTC+8)
    摘要: Background: Establishing animal models with metabolic disorders similar to human metabolic syndrome (MS) is important. In terms of eliciting a full array of MS, we have previously shown that Wistar rats are more responsive to sucrose water drinking than are C57BL/6J mice. This study was aimed at investigating the underlying molecular mechanism of sucrose water-induced MS in Wistar rats. Methods: Male Wistar rats were divided into 2 groups (n = 8 for each group) which were given plain water (C group) or 30% sucrose water (SW group) to drink ad libitum. After 20 weeks, the transcriptional levels and protein translocation of hepatic sterol regulatory element-binding protein-1c (SREBP-1c) and carbohydrate response element-binding protein (ChREBP) as well as the protein levels of protein tyrosine phosphatase-1B (PTP-1B) in insulin-responsive tissues (liver, muscle, and adipose tissue) were measured. Results: The sucrose water regimen successfully elicited visceral obesity, hypertriglyceridemia, insulin resistance, and high blood pressure. The upregulation of de novo lipogenesis in the liver of the sucrose water-treated rats was demonstrated by an increased activity of enzymes, mRNA levels of lipogenic proteins, and nuclear levels of SREBP-1c and ChREBP. Moreover, in the sucrose water-treated rats, protein levels of PTP-1B were significantly increased in liver and skeletal muscle but decreased in adipose tissue. Conclusion: The susceptibility of Wistar rats to sucrose water-induced MS is associated with the transactivation of SREBP-1c and ChREBP in the liver, and PTP-1B is involved in the upregulation of de novo lipogenesis in the liver and the pathology of systemic insulin resistance in rats with MS chronically induced by drinking sucrose water. Copyright [copy 2010 S. Karger AG, Basel
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