Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25222
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    Title: Decreased Expression of Thrombomodulin Is Correlated With Tumor Cell Invasiveness and Poor Prognosis in Nonsmall Cell Lung Cancer
    Authors: Po-Len Liu
    Jong-Rung Tsai
    Chien-Chih Chiu
    Jhi-Jhu Hwang
    Shah-Hwa Chou
    Chih-Kuang Wang
    Shu-Jing Wu
    Yuh-Lien Chen
    Wen-Chi Chen
    Yung-Hsiang Chen
    Inn-Wen Chong
    Contributors: 保健營養系
    Keywords: thrombomodulin
    nonsmall cell lung cancer
    metastasis
    prognosis
    PI3K/Akt
    Date: 2010-10
    Issue Date: 2012-05-21 16:30:00 (UTC+8)
    Abstract: Thrombomodulin (TM) plays a role in coagulation, inflammation, and cell adhesion. Reduction of TM expression
    plays an important role in the tumor metastatic process; however, insufficient information is available regarding the
    expression of TM in nonsmall cell lung cancer (NSCLC). Sixty NSCLC patients who underwent surgery were reviewed
    for TM expression and multiple variables were assessed by univariate and multivariate analyses. The expression level of
    TM and its metastatic ability were examined in vitro using the human NSCLC A549 cell line. TM expression in NSCLC
    was significantly correlated with survival; the 5-yr survival rates of patients with high and low TM expression were
    23% and 18% (P<0.01), respectively. Distribution of TM was detected predominantly in the normal lung tissue
    compared with lung cancer tissue. Western blot analysis showed, on average, decreased expression levels of TM
    protein in the lung cancer tissues of patients with NSCLC. An in vitro study also showed that overexpression of TM can
    inhibit the invasiveness and migration ability of the A549 cell line, whereas silencing of TM significantly enhanced
    these processes. This inhibition of cellular migration by overexpression of TM was significantly prevented by the
    selective inhibitors of PI3K and Akt, but not by MAPK inhibitors. This study demonstrates that a decrease in TM
    expression may be an indicator in the prognosis of NSCLC patients and provides new insights into the molecular
    mechanisms of TM in the metastasis of NSCLC
    Relation: Molecular Carcinogenesis 49:p.874-881
    Appears in Collections:[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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