Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25220
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    標題: Attenuation of circulatory shock and cerebral ischemia injury in heat stroke by combination treatment with dexamethasone and hydroxyethyl starch.
    作者: Tsai-Hsiu Yang
    Mei-Fen Shih
    Yi-Szu Wen
    Wen-Yueh Ho
    Kuen-Lin Leu
    Mei-Ying Wang
    Chia-Chyuan Liu
    貢獻者: 保健營養系
    日期: 2010-09
    上傳時間: 2012-05-21 16:29:58 (UTC+8)
    摘要: Background: Increased systemic cytokines and elevated brain levels of monoamines, and hydroxyl radical
    productions are thought to aggravate the conditions of cerebral ischemia and neuronal damage during heat
    stroke. Dexamethasone (DXM) is a known immunosuppressive drug used in controlling inflammation, and
    hydroxyethyl starch (HES) is used as a volume-expanding drug in cerebral ischemia and/or cerebral injury. Acute
    treatment with a combined therapeutic approach has been repeatedly advocated in cerebral ischemia
    experiments. The aim of this study is to investigate whether the combined agent (HES and DXM) has beneficial
    efficacy to improve the survival time (ST) and heat stroke-induced cerebral ischemia and neuronal damage in
    experimental heat stroke.
    Methods: Urethane-anesthetized rats underwent instrumentation for the measurement of colonic temperature,
    mean arterial pressure (MAP), local striatal cerebral blood flow (CBF), heart rate, and neuronal damage score. The
    rats were exposed to an ambient temperature (43 degrees centigrade) to induce heat stroke. Concentrations of the
    ischemic and damage markers, dopamine, serotonin, and hydroxyl radical productions in corpus striatum, and the
    serum levels of interleukin-1 beta, tumor necrosis factor-alpha and malondialdehyde (MDA) were observed during
    heat stroke.
    Results: After heat stroke, the rats displayed circulatory shock (arterial hypotension), decreased CBF, increased the
    serum levels of cytokines and MDA, increased cerebral striatal monoamines and hydroxyl radical productions
    release, and severe cerebral ischemia and neuronal damage compared with those of normothermic control rats.
    However, immediate treatment with the combined agent at the onset of heat stroke confers significant protection
    against heat stroke-induced circulatory shock, systemic inflammation; cerebral ischemia, cerebral monoamines and
    hydroxyl radical production overload, and improves neuronal damage and the ST in rats.
    Conclusions: Our results suggest that the combination of a colloid substance with a volume-expanding effect and
    an anti-inflammatory agent may provide a better resuscitation solution for victims with heat stroke.
    關聯: Experimental & Translational Stroke Medicine 2(19)
    顯示於類別:[保健營養系(所) ] 期刊論文


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