Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25146
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 17330/19636 (88%)
造访人次 : 4602898      在线人数 : 336
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cnu.edu.tw/handle/310902800/25146


    標題: Inhibition of melanogensis by a novel origanoside from Origanum vulgare
    作者: Chia-Hua Liang
    Tzung-Han Chou
    Hsiou-Yu Ding
    貢獻者: 化粧品應用與管理系
    關鍵字: Origanumvulgare
    Origanoside
    Tyrosinase
    Melanogensis
    日期: 2010-03
    上傳時間: 2012-03-29 13:46:02 (UTC+8)
    摘要: Background
    Natural and synthetic substances are becoming increasingly utilized as tyrosinase inhibitors of depigmentation and developed cosmetics industry. However, few have been employed as skin-whitening agents, primarily because of numerous safety concerns.
    Objective
    Anovel compound was found, and then its safe concentrations and inhibition effect of hyperpigmentation by the regulation of the tyrosinase family of proteins were examined.
    Methods
    Anovel phenolic glucoside, origanoside (1), was isolated fromOriganumvulgare. The structure of the origanoside (1) was established on the basis of spectral evidence and the safe concentrations were determined by MTT assay. Skin-whitening capacity in skin fibroblast Hs68 and melanoma B16 cells and in vivo animal test for origanoside (1) were investigated.
    Results
    Origanoside (1) is non-toxic in concentrations of 0–100 μg/ml in both cells. The ability oforiganoside (1) to inhibit cellular tyrosinase and DOPA oxidase in B16 cells was investigated. Origanoside (1) significantly reduced expressions of microphthalmia-associated transcription factor (MITF), tyrosinase and tyrosinase-related proteins 2 (TRP-2) in vitro and in vivo, suggesting that origanoside (1) is responsible for the antimelanogenic effect. Smearing origanoside (1)-gel samples on 12 mice for 10 days increased L*, reduced a* and erythema-melanin (E/M), and b* was almost unchanged compared with those of samples and untreated groups, indicating that the skin lightened.
    Conclusion
    Experimental data demonstrate that origanoside (1) causes depigmentation and may be useful for novel food additives and skin-whitening cosmetics.
    關聯: Journal of Dermatological Science 57(3):p.170-177
    显示于类别:[化妝品應用與管理系(所)] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    99_16_j.pdf599KbAdobe PDF548检视/开启
    index.html599KbHTML774检视/开启


    在CNU IR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈