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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/25134


    標題: Inhibition of Melanogenesis and Oxidation by Protocatechuic Acid from Origanum Vulgare (Oregano)
    作者: Tzung-Han Chou
    Hsiou-Yu Ding
    Rong-Jyh Lin
    Jing-Yao Liang
    Chia-Hua Liang
    貢獻者: 化粧品科技研究所
    日期: 2010-11
    上傳時間: 2012-03-29 13:45:51 (UTC+8)
    出版者: Amer Chemical Soc
    摘要: Antioxidant and antimelanogenesis activities of protocatechuic acid (1) from Origanum Vulgare (oregano) were investigated. The antioxidative capacity of 1 was confirmed from its free-radical-scavenging activities, inhibition of lipid peroxidation, and suppression of reactive oxygen species in H2O2-induced BNLCL2 cells. The inhibition by 1 of tyrosinase and DOPA oxidase activity and melanin production was possibly related to the down-regulation of melanocortin-1 receptor, microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related proteins-2, and tyrosinase-related proteins-1 expression in R-melanocyte-stimulating hormone-induced B16 cells. After a gel containing 1 was applied to mice, the values of L* slightly increased, and a* and erythema-melanin levels of skin were reduced by comparing the values of untreated control groups, indicating 1 can reduce melanin production. These results suggest
    that 1 may act as an effective quencher of oxidative attackers with antimelanogenesis properties.
    關聯: Journal of Natural Products 73(11):p.1767-1774
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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