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    請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/24875


    標題: 同半胱胺酸於細胞缺氧與動物熱中風模式中對細胞介質素和自由基之影響
    Effects of Homocysteine on Expression of Cytokines and Free Radicals in Cell Culture under Hypoxic Condition and the Animal Heatstroke Model
    作者: 劉家全
    溫義嗣
    貢獻者: 化妝品應用與管理系
    關鍵字: 高同半胱胺酸血症
    熱中風
    葉酸與維生素B12
    缺氧/缺血
    hyperhomocysteinemia
    heatstroke
    folic acid and vitamin-B12
    hypoxia/ischemia
    日期: 2010
    上傳時間: 2011-12-22 09:47:24 (UTC+8)
    摘要: 事先飲食補充葉酸與維生素B12 對高
    同半胱胺酸血症大鼠(經由餵食高單
    位甲硫胺酸所誘發)改善熱中風病理
    生理參數變化和傷害影響之探討---
    我們經由給予飲食處理高單位甲硫胺
    酸,來提升大鼠血中同半胱胺酸濃度
    誘發生成高同半胱胺酸血症,並評估
    對大鼠熱中風所致損傷的影響情況。
    在此一試驗中,我們再次確認HCY 參
    與在熱中風所致損傷病理生理發展的
    角色,而且證實高同半胱胺酸血症可
    能可視為是熱中風發生率的危險因
    子。我們推論HCY 不僅是心血管和神
    經疾病熟知的危險因子,也可能是與
    促進細胞介質素和自由基有關熱中風
    的危險因子。目前,沒有一個治療策
    略可以完全改善熱中風所造成的損
    傷,因此從日常預防觀點來減低熱中
    風的發生率和死亡率是很重要的。充
    足的葉酸與維生素B12 狀態可透過飲
    食補充,在降低血中高濃度HCY 扮演
    重要角色。現今實驗成果,我們論證
    在高同半胱胺酸血症大鼠中,經飲食
    補充葉酸和維生素-B12 後,可透過減
    低上升的細胞介質素和自由基,而達
    到改善因熱中風所致循環休克、腦缺
    氧、缺血和神經損傷的情形。
    Investigation of effects of the folic acid
    and vitamin-B12 dietary
    supplementation in advance on
    improving the pathophysiologic
    parameters changes and damage during
    heatstroke in hyperhomocysteinemic
    rats (induced by feeding with diet of
    high content methionine). We raised the
    systemic levels of HCY to produce
    circulating hyperhomocysteinemia via
    giving high content methionine diet, and
    then estimate the influence on the
    heatstroke-induced damage in rats. In
    this experiment, we confirm again the
    role of HCY in pathophysiologic
    development of heatstroke-induced
    damage, and demonstrated that
    hyperhomocysteinemia may be viewed
    as a risk factor for heatstroke incidence.
    We speculate that HCY, a known risk
    factor for other cardiovascular and
    neuronal diseases, can be also a risk
    factor for heatstroke associated with the
    increased cytokines and free radicals.
    Until now, no one therapeutic strategy
    could be effective to completely
    improve the heatstroke-induced damage.
    It will be more important to diminish the
    heatstroke incidences and mortality rate
    from the viewpoint in regular
    prophylaxis. The sufficient folate and
    vitamin-B12 statuses, which can be
    achieved through folate and
    vitamin-B12 dietary supplementation,
    may play a critical role in lowering
    elevated HCY concentrations. In present
    study, we found that dietary
    supplementation with folic acid and
    vitamin-B12 in rats with
    hyperhomocysteinemia may ameliorate
    the heatstroke-induced circulatory shock,
    cerebral hypoxia, ischemia and neuronal
    damage by attenuating the increased
    cytokines and free radicals.
    關聯: 計畫編號:NSC97-2314-B041-001-MY3
    計畫年度:99;起迄日期:2010-08-01~2011-07-31
    核定金額:950,000元
    顯示於類別:[化妝品應用與管理系(所)] 科技部計畫

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