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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/24514

    標題: 雙陽離子聚離子液體的合成及抗菌性能之研究
    Synthesis and Antimicrobial Activity of Dicationic Poly (Ionic Liquid)s
    作者: 謝欣秀
    貢獻者: 嘉南藥理科技大學:化妝品科技研究所
    關鍵字: 最低殺菌濃度
    minimal inhibitory concentration
    minimal microbicidal concentration
    disc diffusion assay
    dicationic poly (ionic liquid)s
    日期: 2011
    上傳時間: 2011-10-25 13:28:24 (UTC+8)
    摘要: 本研究以離子液體結構為基礎,開發出8種雙陽離子聚離子液體,接著經由(1)紙錠擴散試驗(disc diffusion assay)與(2)最低抑菌濃度(minimal inhibitory concentration, MIC)及最低殺菌濃度(minimal microbicidal concentration, MMC)之方法評估抗菌性能,探討聚離子液體中不同的陽離子結構對抗菌效能之影響。
    This thesis is based on the structures of ionic liquids to develop eight types of dicationic poly(ionic liquid)s. And then the antimicrobial efficacy is evaluated by the methods of (1) disc diffusion assay, (2) MIC (minimal inhibitory concentration) and MMC (minimal microbicidal concentration) to investigate the antimicrobial efficacy affected by alkyl chain with different types of cations.
    The results of disc-diffusion assay display that the dicationic poly(ionic liquid)s (25a-25h) show better antibacterial performance for Gram-positive bacteria (S.aureas) and fungi (C. albicas) than dicationic ionic liquid monomers (25a-25h). the possible factor is that the charge density of poly(ionic liquid)s is higher than their corresponding monomers and contributes the adsorption interaction with bacteria to execute the antibacterial performance. Dicationic poly(ionic liquid)s (26h) has the best minimum inhibitory concentration for studying the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MMC) of the fungi (C. albicas). The values of minimum inhibitory concentration is respectively 110μg/mL (26h), and the values of minimum bactericidal concentration are also respectively 131.7μg/mL (26h).
    關聯: 校內校外均不公開
    Appears in Collections:[化妝品應用與管理系(所)] 博碩士論文

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