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    標題: The Absolute Bioavailability of Rabbit Muscle Creatine Phosphokinase after Intramuscular Administration
    作者: Hsingchu Hsu
    Jun Watanabe
    貢獻者: 藥學科
    關鍵字: rabbit muscle creatine phosphokinase
    clearance/body weight
    intramuscular administration
    mean residence time
    mean absorption time
    variance of residence time
    fraction of absorption
    日期: 1987
    上傳時間: 2011-10-24 14:19:38 (UTC+8)
    摘要: A two-period crossover study was carried out to dctermine the rate and the extent of bioavailability of rabbit muscle creatine phosphokinase (CPK) after intramuscular administration to six male rabbits. The plasma prohfile of CPK after intramuscular administration (500 U/kg body weight in 0.8 ml of 2% rabbit serum albumin solution into the vastus lateralis muscle) showed a plateau around 4--12 h. Intravenous administration of CPK was performed at doses of 300 and 500U/kg body weight.The mean clearance/body weight and Vd/body weight were 0.00604 +- 0.00094 l/h/kg (mean +-S.D., n=6) and 5.32 +- 1.47%, respectively. The mean residence time (MRTim) and mean absorption time (MATim) of CPK after intramuscular administrationwere 20.7 +- 4.2 and 11.9 +- 5.1 h, respectively. Since MATim was long relative to MRTim, the rate of bioavailability was slow and the residence time distribution appeared to be skewed. The value of MATim/MRTim, reflecting the contribution of moment of input function to the plasma activity of CPK, was 55.4 +- 11.6%. The variance of residence time (VRTim) and variance of absorption time( VATim) were 608 +- 107 and 505 +- 122 h2. The results imply that the aborption and disposition of CPK after intramuscular administration were rather complicated.The mean fraction of CPK absorbed. was 0.311 +- 0. 149. Presumably, the incomplete access of CPK to the systemic circulation was due to extravascular inactivation.
    關聯: 嘉南學報 13:A32-A38 轉載 Chemical & pharmaceutical bulletin 32(5) : p.1922-1928 (1984)
    顯示於類別:[嘉南學報] 13期 (1987)
    [藥學系(所)] 期刊論文

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