Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/24366
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    Title: Emesis Induced by Cancer Chemotherapeutic Agents in the Suncus Murinus: A New Experimental Model
    Authors: Norio MATSUKI
    Shinya UENO
    Takahide KAJI
    Akane ISHIHARA
    Chao-Hsiung WANG
    Hiroshi SAITO
    Date: 1988
    Issue Date: 2011-10-06 11:21:11 (UTC+8)
    Abstract: Acute emetic responses to seven cancer chemotherapeutic agents (adriamycin, bleomycin, cisplatin, cyclophosphamide, 5-fluorouracil, methotrexate, mitomycin C) were studied in the Suncus murinus. Intravenous injection of the drugs caused vomiting with various latency. Cisplatin-induced emesis was prevented by the pretreatment with metoclopramide or chlorpromazine but not with domperidone. These results indicate that the Suncus murinus is a useful animal for testing emetic activities of cancer chemotherapeutics and antiemetic activities of prophylactic drugs.
    Appears in Collections:[Chna Nan Annual Bulletin] Vol.14 (1988)

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