Vasodilator Effect of Different Extractive Methods of Ginger extracts on jrorcine coronary Arteries

CNU IR > Pharmacy and Science > 2011 Taiwanese-Russian Organic, Medicinal and Bio Chemistry Interactions & PST Medicinal Chemistry Symposium > Item 310902800/24255

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Title:	Vasodilator Effect of Different Extractive Methods of Ginger extracts on jrorcine coronary Arteries
Authors:	Ming-Chi Hung (洪明吉) Po-ChuenShieh (謝博銓) Fu-An Chen (陳福安) Hsu-shoucheng (徐守正) Sh-Ben Wang (王翠彬) Daih-Huang Kuo (郭代磺)
Date:	2011
Issue Date:	2011-06-23 14:57:40 (UTC+8)
Abstract:	An investigation into the vasodilator effects of chloroform, n-butanol and reverse osmosis water extraction of the extracts of ginger {Zingiber officinale Rose.) on porcine coronary arteries. The right coronary arteries were harvested from a local slaughterhouse , carefully dissected out, and cut into 5-mm rings. All rings were subjected stepwise to a predetermined optimal tension of 3 g and allowed to equilibrate for 30 minutes. Alter equilibration, each ring was induced contraction by potassium chloride. The vasodilator curves were obtained with 5 cumulative additions of extracts (1,3, 10, 30 and 100 ppm). Isometric tension was measured using Cyber 380 and Digidata 1320A instruments and readings were recorded in a computer system. Our result revealed that the extracts of n-butanol and reverse osmosis water extraction had hardly vasodilator effect. The relaxant extents of various doses chloroform extract (1, 3, 10, 30 and 100 ppm) were 6�5 - 19�10 - 40�9 - 70�9 - 100� 0%. The result demonstrates that chloroform extract of ginger possesses vasodilator activity in a dose dependant manner. The possibly physiological relaxation mechanisms involved, vascular protection, scavenging free radicals, anti-oxidative effect, anti-inflammatory activity and related physiological mechanisms will also be surveyed.
Relation:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
Appears in Collections:	[Pharmacy and Science] 2011 Taiwanese-Russian Organic, Medicinal and Bio Chemistry Interactions & PST Medicinal Chemistry Symposium

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