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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/23265


    標題: Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia
    作者: Hung-Yuan Li
    Jung-Nan Wei
    Mao-Shin Lin
    David J. Smith
    Jani Vainio
    Cheng-Hsin Line
    Fu-Tien Chiang
    Shyang-Rong Shih
    Ching-Huei Huang
    Mei-Yu Wu
    Yenh-Chen Hsein
    Lee-Ming Chuang
    貢獻者: 職業安全衛生系
    關鍵字: Semicarbazide-sensitive amine oxidase
    Vascular adhesion protein-1
    Amine oxidase
    Copper-containing 3 (AOC3)
    Diabetes mellitus
    Diabetic complications
    日期: 2009-06
    上傳時間: 2010-11-19 11:50:22 (UTC+8)
    摘要: Background
    The relationship between serum vascular adhesion protein-1 (VAP-1) and plasma glucose in normal and drug-naïve type 2 diabetes subjects is unclear. We examined if serum VAP-1 changed acutely to oral glucose loading and analyzed the relationship between serum VAP-1, fasting plasma glucose (FPG), hemoglobin A1c, and type 2 diabetes.

    Methods
    Adults without history of diabetes were included. Subjects taking anti-diabetic drugs were excluded. Serum VAP-1 was analyzed by time-resolved immunofluorometric assay.

    Results
    We recruited 333 subjects (186 females and 147 males), aged 56.1 ± 11.6 y. After glucose challenge, serum VAP-1 rose significantly at 30 min (p < 0.0001) and lasted until 2 h (p < 0.0001). The change of serum VAP-1 between fasting and 30-min postload correlated inversely to the change of plasma insulin (r = − 0.21, p = 0.049). Fasting serum VAP-1 was associated with FPG in those with FPG ≥ 5.55 mmol/l (p = 0.025) but not in those with FPG < 5.55 mmol/l (p = NS). Fasting serum VAP-1 were higher in diabetic subjects (p = 0.04) and correlated positively to hemoglobin A1c (r = 0.18, p = 0.002) after adjusting for age, gender, and waist circumference.

    Conclusions
    Serum VAP-1 is increased in both acute and chronic hyperglycemia. Whether serum VAP-1 is a good biomarker for hyperglycemia-associated complications merits further investigation.
    關聯: Clinica Chimica Acta 404(2):p.149-153
    Appears in Collections:[職業安全衛生系(含防災所)] 期刊論文

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