Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/23213
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    Title: New cytotoxic withanolides from Physalis peruviana
    Authors: Yu-Hsuan Lan
    Fang-Rong Chang
    Mei-Jung Pan
    Chin-Chung Wu
    Shu-Jing Wu
    Su-Li Chen
    Shyh-Shyan Wang
    Ming-Jung Wu
    Yang-Chang Wu
    Contributors: 保健營養系
    Keywords: Physalis peruviana L.
    Withanolides
    Phyperunolide A–F
    Peruvianoxide
    Cytotoxicity
    Date: 2009-09
    Issue Date: 2010-11-12 16:11:29 (UTC+8)
    Abstract: Investigation of the extracts of Physalis peruviana L. has led to the isolation of seven new withanolides, phyperunolide A (1), phyperunolide B (2), phyperunolide C (3), phyperunolide D (4), peruvianoxide (5), phyperunolide E (16), and phyperunolide F (17) together with ten known withanolides. The structure and absolute stereochemistry of all compounds were elucidated on the basis of CD and NMR spectral analysis, respectively. Compounds 1, 6, 7, and 9 showed cytotoxicity against lung cancer (A549), breast cancer (MDA-MB-231 and MCF7), and liver cancer (Hep G2 and Hep 3B) cancer cell lines. The presence of 5β,6β-epoxy-2-en-1-ones in withanolides is greatly helpful in cytotoxicity, it is a key known important factor to cytotoxicity; however, interestingly, the unusual 5-chloride withanolide, 9, displayed significant activity.
    Appears in Collections:[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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