Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/23178
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    標題: 番椒晶素及SNA對人類血小板的抑制作用
    Studies on the Antiplatelet Activities of Capsaicin and SNA
    作者: 楊竹茂
    游慧美
    高惠珍
    傅利芳
    貢獻者: 藥學科
    關鍵字: 番椒晶素
    SNA
    抗血小板凝集活性
    ADP
    膠原旦白
    血小板活化因子
    capsaicin
    sdium nonivamide acatate
    anti-platelet activity
    ADP
    collagen
    PAF
    日期: 1994
    上傳時間: 2010-11-10 18:22:23 (UTC+8)
    摘要: 本研究旨在探討番椒晶素語合成的同類物SNA(Sodium Nonivamide Acetate)的抗血小板凝集作用之活性與機轉,由一系列實驗顯示:二者皆能抑制膠原蛋白所誘發之血小板凝集作用;番椒晶素顯示對綿羊精囊微粒體催化花生烯酸產生前列腺素E2具有強烈的抑制作用,然而SNA並無此作用;兩者對徑indomethacin處理與未處理之人體血小板微粒體(IPM)催化花生烯酸所產生的凝血素B2具有劑量相關性的抑制作用;兩者皆能抑制以螺旋條狀的兎主動脈所進行的生物檢測法中,由IPM催化前列腺素內過氧化物產生凝血素
    The aim of this study is to investigate the and-platelet aggregation activities and the possible mechanisms of action of capsaicin (CAP) and the synthetic analogue-SNA (Sodium Nonivamide Acetate). The results obtained from a series of experiments demonstrated that both cmpounds in-hibited the platelet aggregation induced by collagen; CAP also showed a strong inhibition on PGE2 formation from 【14C】 A.A. by sheep seminal vesicle (SSV) microsomes, while SNA did not have this effect. Both drugs produced a dose-dependent inhibition of TXB2 formation from【14C】A.A. by human platelet microsomes and from PG-endoperoxides by indomethacin-treated human platelet microsomes (IPM). In the bioassay with spiral strip of rabbit-aorta, both drugs inhibited the formation of TXA2-like form PG-endoperoxides by IPM. In conclusion, the anti-platelet effect of SNA might be due to the selective inhibition of thro-mboxane synthetase activity in human platelets.
    顯示於類別:[嘉南學報] 20期 (1994)
    [藥學系(所)] 期刊論文

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