Small volume resuscitation in a rat model of heatstroke

doi:10.1097/MAJ.0b013e31817da198

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/23132

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/23132

Title:	Small volume resuscitation in a rat model of heatstroke
Authors:	Liu, Chia-Chyuan Cheng, Bor-Chih Lin, Mao-Tsun Lin, Hung-Jung
Contributors:	化粧品應用與管理系
Keywords:	Hyper-HAES Heatstroke Multiorgan dysfunction Coagulation Inflammation Hypotension Cerebral ischemia
Date:	2009-02
Issue Date:	2010-10-26 16:06:55 (UTC+8)
Abstract:	BACKGROUND: Herein, we compared the effectiveness of different small volume resuscitation in a rat model of heatstroke. METHODS: Anesthetized rats, immediately after the onset of heatstroke, were randomly divided into 5 groups and given the following: (a) nothing; (b) 0.9% NaCl (1-10 mL/kg of body weight, i.v.); (c) hydroxyethyl starch (HAES) (6%, 1-10 mL/kg of body weight, i.v.); (d) 7.2% NaCl (1-10 mL/kg of body weight, i.v.); and (e) hyper-HAES (6% HAES plus 7.2% NaCl, 1-10 mL/kg of body weight, i.v.). RESULTS: When the untreated or 0.9% NaCl (1-5 mL/kg of body weight)-treated rats underwent heat stress, their survival time values were found to be 20 to 22 minutes. Resuscitation with 10 mL/kg of body weight of 0.9% NaCl, 6% HAES, 7.2% NaCl, or hyper-HAES, their survival time values, respectively, are 93+/-6, 101+/-12, 154+/-18, or 286+/-21. Apparently, the order of effectiveness in resuscitation of heatstroke is hyper-HAES>7.2% NaCl>0.9% NaCl or 6% HAES. The heatstroke-induced hypotension, cerebral ischemia and hypoxia, hypercoagulable state, activated inflammation, and hepatic and renal dysfunction can be significantly reduced by hyper-HAES. CONCLUSIONS: Our results suggest that hyper-HAES seems superior to 7.2% NaCl or HAES alone in resuscitation of heatstroke. The benefit of hyper-HAES during heatstroke is related to restoration of normal multiorgan function.
Relation:	Am J Med Sci. 337(2)：p.79-87
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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