Medication safety is a primary component of a comprehensive safety program and an integral part of quality patient care. The most important issues for WHO, European countries, or US are promotion of the patient safety and diminishing medical error. It is also the main emphasis on healthcare administration in Taiwan. The first aim of patient safety is to elevate the drug safety. The goal can be accomplished not only in the good connection and cooperation of patient and medical staff, hut also in the enforcement of drug safety knowledge and proper behavior of taking drug for patient. To address the public health problem of outpatient drug safety, we investigated the perception of drug safety, behavior, patient-medical professionals communication and, from the patient's point of view, the fulfillment of drug safety in medical staff. One medical center and one regional hospital in northern Taiwan were chosen as the survey targets, for their outstanding record in promoting medical quality and specific management department in charge with relative affairs. We investigated six main categories of drug safety by delivering 400 questionnaires, which included the inquiry of drug usage, patient-medical professionals communication, the labeling on drug bag, confirm processes during having drug, the accuracy in taking drug and the storage of drug. Our results show that: 1. The satisfaction for drug inquiry of hospital, the drug safety behavior of medical staff and the service of pharmacist were below 60%. 2. Female, those who were above 31-year, or who had medical service for 3~10 times past half year have the better patient-medical professionals communication. Higher educated patient would double check the medicine information from the pharmacy. When taking the medicine, older patients (>51 years old) were more careful and correct. 3. The execution of drug safety policy by staff in medical center was significantly better than that in regional hospital. The expectations of patient were a safer medical environment, as well as effective and harm-free medication. To assure safe therapy, the following should be addressed: first, more financial aid should be provided for the study of medication, and second, hospitals should provide drug consultation for patient, and make sure that patient have access to the full facts of understanding drug safety. The intervention of the aid of complementary computer system will help conceptualize patient drug safety, and establish an accurate drug delivery and recording system for preventing medical staff from any possible artifacts beforehand.