Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/22794
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 17524/19853 (88%)
Visitors : 6385296      Online Users : 674
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    CNU IR > Chna Nan Annual Bulletin > Vol.35 (2009) >  Item 310902800/22794
    Please use this identifier to cite or link to this item:

    Title: Characterization and Determination of Fexofenadine with Its Synthetic Intermediate Compounds by HPLC-UV Method
    Authors: Tzu-Chueh Wang
    Chung-Wei Pai
    Tz-Chiang Tang
    Contributors: 藥學系
    Keywords: HPLC-UV分析
    Fexofenadine hydrochloride
    Date: 2009
    Issue Date: 2010-09-10 09:09:05 (UTC+8)
    Abstract: A simple and rapid isocratic HPLC-UV method for the routine quality control of fexofenadine hydrochloride in synthesis products has been established. By using iethylamine-phosphoric acid aqueous solution (O.10 mol/L) / methanol (45:55) mobile phase (flow rate 1.O mL/min) and ODS column at ambient temperature, fexofenadine hydrochloride can be well separated hom its 3 major synthetic intemlediate impurities in 15 minutes.The representative linear equation of the method was Y = 1.103xl0X - 1.186xl03, where X is the concentration of fexofenadine hydrochloride and Y is the peak area, with conelation coefficient(R) of O.9999 (n=3). The limit of quantitation (LOQ) and limit of detection (LOD) ofthe proposed method were 180 ng and 60 ng, respectively. The RSD of intra-and inter-day precision test ofthe method were O.43% and O.28%, respectively, whtch had snowil yi caL promilse in the quality control routine analysis of fexofenadine hydrochloride. The proposed method was demonstrated in degradation test of fexofenadine hydrochloride.
    本篇研究對鹽酸菲索非那定及其合成過程中的中間產物,建立以HPLC-UV方法進行特性分析。在最佳化情況下,可在15分鐘內對鹽酸菲索非那定與三種主要中間產物混合液分離而得到良好的層析圖譜,訊號與濃度線性關係測定的結果,為Y = 1.103x103X - 1.186x103,r= 0.9999 (n=3),具有良好的線性關係,而同日間精密度(Intra-day precision)與異日間精密度(Inter-day precision)之測定RSD分別為+/- 0.43%與+/-0.28% ,其準確度則與使用傳統非水滴定法測定結果具有一致性。
    Relation: 嘉南學報(科技類) 35:p.92-100
    Appears in Collections:[Chna Nan Annual Bulletin] Vol.35 (2009)
    [Dept. of Pharmacy] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    v35_92_100.pdf7899KbAdobe PDF475View/Open

    All items in CNU IR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback