Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/22766
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    CNU IR > Chna Nan Annual Bulletin > Vol.24 (1998) >  Item 310902800/22766
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    Title: Interaction Of Norfloxacin with Phospholipids in Liposomes and Their Stability
    Authors: Hung-Hong Lin
    Li-Ren Hsu
    Tzu-Chueh Wang
    Yi-Hung Tsai
    Contributors: 藥學系
    Keywords: leisure sports experiencing
    reliability validity
    conformational anaiysis
    Date: 1998
    Issue Date: 2010-05-11 14:10:17 (UTC+8)
    Abstract: Two perparation procedures were carried out to encapsulate norfloxacin into liposomes.The interaction of norfloxacin with phospholipids in liposomes was investigated by using differential scanning calorimetry and conformational analysis.The long term stability of liposomal drug was studied by measuring the leakage of norfloxacin at various storage conditions.These results indi-cated that,for liposomes prepared through the ethanol injection and freeze-drying processes,norfloxacin was not only encapsulated within the liposomes cavity but also bound to the lipid bilayer.Thus,the drug encapsulation inside liposomes was increased.For the long term stability,the results suggested that liposomes should be stored in the state of lyophilized powder at lower temperature and reconstitute by adding double-distilled before used.
    Relation: 嘉南學報 24期 : p.86-94
    Appears in Collections:[Chna Nan Annual Bulletin] Vol.24 (1998)
    [Dept. of Pharmacy] Periodical Articles

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