A Molecular Dynamics Simulation of the Human Lysozyme–Camelid VHH HL6 Antibody System

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標題:	A Molecular Dynamics Simulation of the Human Lysozyme–Camelid VHH HL6 Antibody System
作者:	Zhi-Yuan Su Yeng-Tseng Wang
貢獻者:	資訊管理系
關鍵字:	Molecular dynamics amyloid diseases lysozyme atomic force microscopy
日期:	2009-04
上傳時間:	2010-04-13 14:16:03 (UTC+8)
摘要:	Amyloid diseases such as Alzheimer’s and thrombosis are characterized by an aberrant assembly of specific proteins or protein fragments into fibrils and plaques that are deposited in various tissues and organs. The single-domain fragment of a camelid antibody was reported to be able to combat against wild-type human lysozyme for inhibiting in-vitro aggregations of the amyloidogenic variant (D67H). The present study is aimed at elucidating the unbinding mechanics between the D67H lysozyme and VHH HL6 antibody fragment by using steered molecular dynamics (SMD) simulations on a nanosecond scale with different pulling velocities. The results of the simulation indicated that stretching forces of more than two nano Newton (nN) were required to dissociate the proteinantibody system, and the hydrogen bond dissociation pathways were computed.
關聯:	International Journal of Molecular Sciences 10(4)：p.1719-1727
显示于类别:	[資訊管理系] 期刊論文

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A Molecular Dynamics Simulation of the Human Lysozyme–Camelid VHH HL6 Antibody System .pdf	A Molecular Dynamics Simulation of the Human Lysozyme–Camelid VHH HL6 Antibody System	396Kb	Adobe PDF	1135	检视/开启

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