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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/22606


    標題: A Molecular Dynamics Simulation of the Human Lysozyme–Camelid VHH HL6 Antibody System
    作者: Zhi-Yuan Su
    Yeng-Tseng Wang
    貢獻者: 資訊管理系
    關鍵字: Molecular dynamics
    amyloid diseases
    lysozyme
    atomic force microscopy
    日期: 2009-04
    上傳時間: 2010-04-13 14:16:03 (UTC+8)
    摘要: Amyloid diseases such as Alzheimer’s and thrombosis are characterized by an
    aberrant assembly of specific proteins or protein fragments into fibrils and plaques that are
    deposited in various tissues and organs. The single-domain fragment of a camelid antibody
    was reported to be able to combat against wild-type human lysozyme for inhibiting in-vitro
    aggregations of the amyloidogenic variant (D67H). The present study is aimed at
    elucidating the unbinding mechanics between the D67H lysozyme and VHH HL6 antibody
    fragment by using steered molecular dynamics (SMD) simulations on a nanosecond scale
    with different pulling velocities. The results of the simulation indicated that stretching
    forces of more than two nano Newton (nN) were required to dissociate the proteinantibody
    system, and the hydrogen bond dissociation pathways were computed.
    關聯: International Journal of Molecular Sciences 10(4):p.1719-1727
    Appears in Collections:[資訊管理系] 期刊論文

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