| 摘要: | 外因性內分泌干擾物質(endocrine disrupter compounds)又被稱為環境荷爾蒙(environmental hormone)，此等化學物質進入生物體內後形成假性荷爾蒙，傳遞錯誤的化學訊號，干擾生物體內的內分泌系統，造成生物體內分泌失調；進入水體後，首先造成水域生態系統的衝擊，甚至影響陸域生態系統，並且危害人體健康。因此，評估水域中環境荷爾蒙對環境生態及人類健康所造成的危害也就顯得格外的重要。本研究計畫應用臺灣溪流中常見沼蝦(Macrobrachium sp.)對環境荷爾蒙的生理變化來評估水域中環境荷爾蒙—類雌性素(xeno-estrogen或estrogen-like)的危害。計劃分成三年實行，各年達成研究目標如下：第一年的研究目標為主要以vitellogenin(卵黃前質素)、testosterone(雄性素)及estradiol(雌性素)為生理指標瞭解沼蝦對雌性素(17β-estradiol)、壬基苯酚 (nonylphenol)及bisphenol A的反應；第二年的研究目標為應用吊掛網方式來尋找最適合作為指標物種的沼蝦種類；第三年的研究目標為應用選定的沼蝦種類來評估臺灣地區淡水河、頭前溪、大甲溪、北港溪、曾文溪、二仁溪、東港溪、秀姑巒溪及卑南溪等9條河川中水體中類雌性素的危害，並藉此結果評估水體中類雌性素之危害。期待此三年的研究成果可以提供水域中環境荷爾蒙的重要資料。
Environmental contaminants that can affect the endocrine system in animals, which controls important functions through communication of glands, hormones and cellular receptors, are known as endocrine disrupting compounds (EDCs). Widespread exogenous EDCs in the environment are becoming a major growing concern in the field of ecology and environmental protection recently, especially in freshwater ecosystem. Therefore, assess damaging EDCs with freshwater ecosystem is one of the most significant studies of the subject. This project will extend the research project of 2012 year, proposes three-year research work to study the assess with EDCs in freshwater ecosystem by the physiological changes that the concentration of vitellogenin, testosterone, and estradiol in Macrobrachium sp. First-year’s work: aim at the effect of 17β-estradiol, nonylphenol and bisphenol A in Macrobrachium sp. Second year, we continue studying EDCs, chlordane、lindane and DDT affect with shrimp and what’s more proceeded to Net Cage to found indicator species of Macrobrachium sp. Third year, we catch shrimp from nine river, including Danshiuei river, Toucian river, Dajia river, Beigang river, Zengwang, Erren river, Donggang river, Siouguluan river and Beinan river in Taiwan to assess damage with EDCs in freshwater ecosystem. Hopefully, the results of this series research work will be useful as reference for managing and protecting freshwater ecosystem in the future. |
