English  |  正體中文  |  简体中文  |  Items with full text/Total items : 17419/19718 (88%)
Visitors : 6185802      Online Users : 732
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/22286

    標題: Cytopiloyne, a polyacetylenic glucoside, prevents type 1 diabetes in nonobese diabetic mice
    作者: Cicero Lee-Tian Chang
    Shu-Lin Chang
    Yi-Mei Lee
    Yi-Ming Chiang
    Da-Yung Chuang
    Hui-Kai Kuo
    Wen-Chin Yang
    貢獻者: 藥物科技研究所
    日期: 2007-06
    上傳時間: 2010-01-15 14:39:45 (UTC+8)
    摘要: Some polyacetylenes from the plant Bidens pilosa have been reported to treat diabetes. In this study, we report that the cytopiloyne from B. pilosa, which is structurally different from the above-mentioned polyacetylenes and inhibits CD4(+) T cell proliferation, effectively prevents the development of diabetes in nonobese diabetic mice as evidenced by a normal level of blood glucose and insulin and normal pancreatic islet architecture. Cytopiloyne also suppresses the differentiation of type 1 Th cells but promotes that of type 2 Th cells, which is consistent with it enhancing GATA-3 transcription. Also, long-term application of cytopiloyne significantly decreases the level of CD4(+) T cells inside pancreatic lymph nodes and spleens but does not compromise total Ab responses mediated by T cells. Coculture assays imply that this decrease in CD4(+) T cells involves the Fas ligand/Fas pathway. Overall, our results suggest that cytopiloyne prevents type 1 diabetes mainly via T cell regulation.
    關聯: The Journal of Immunology 178(11): p.6984-6993
    Appears in Collections:[藥學系(所)] 期刊論文

    Files in This Item:

    File SizeFormat

    All items in CNU IR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback