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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/22284

    標題: Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator
    作者: Yi-Ming Chiang
    Cicero Lee-Tian Chang
    Shu-Lin Chang
    Wen-Chin Yang
    Lie-Fen Shyur
    貢獻者: 藥物科技研究所
    關鍵字: Bidens pilosa
    Polyacetylenic glucoside
    T cell differentiation
    日期: 2007-04
    上傳時間: 2010-01-15 14:39:41 (UTC+8)
    出版者: Elsevier Ireland Ltd
    摘要: An extract of Bidens pilosa, an anti-diabetic Asteraceae plant, has recently been reported to modulate T cell differentiation and prevent the development of non-obese diabetes (NOD) in NOD mice. In this paper, a novel bioactive polyacetylenic glucoside, cytopiloyne (1), was identified from the Bidens pilosa extract using ex vivo T cell differentiation assays based on a bioactivity-guided fractionation and isolation procedure. Its structure was elucidated as 2β-d-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne by various spectroscopic methods. Functional studies showed that cytopiloyne was able to inhibit the differentiation of naïve T helper (Th0) cells into type I T helper (Th1) cells but to promote the differentiation of Th0 cells into type II T helper (Th2) cell. Accordingly, cytopiloyne also suppressed IFN-γ expression and promoted IL-4 expression in mouse splenocytes ex vivo. These results suggest that cytopiloyne functions as a T cell modulator that may directly contribute to the ethnopharmacological effect of Bidens pilosa extract on preventing diabetes. Moreover, cytopiloyne can serve as an index compound for quality control of lot-to-lot extract preparations of Bidens pilosa.
    關聯: Journal of Ethnopharmacology 110(3): p.532-538
    Appears in Collections:[藥學系(所)] 期刊論文

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