Antioxidant and antihepatoma activities of palm oil extract

doi:10.1111/j.1745-4522.2007.00075.x

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 保健營養系(所) > 期刊論文 > Item 310902800/22225

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標題:	Antioxidant and antihepatoma activities of palm oil extract
作者:	Shu-Jing Wu Lean-Teik Ng
貢獻者:	營養與保健科技研究所
日期:	2007-06
上傳時間:	2010-01-15 11:13:31 (UTC+8)
摘要:	Palm oil extract (POE) at different concentrations (0.1–500 µg/mL) was evaluated for antioxidant and antihepatoma activities. Results showed that POE exhibited a greater antioxidant activity than α-tocopherol in all model systems tested. At concentrations of 0.1–100 µg/mL, POE showed a superoxide radical scavenging activity ranging from 50.6 to 100%, with an IC50 value (0.09 µg/mL) lower than α-tocopherol (0.51 µg/mL). In the xanthine oxidase inhibition test, POE (IC50 = 0.67 µg/mL) also exhibited a stronger inhibitory effect on xanthine oxidase activity than α-tocopherol (IC50 = 0.83 µg/mL). At concentrations of 0.1 µg/mL and above, POE showed significant ability in inhibiting the oxidative damage to lipids induced by ascorbate-Fe2+ than α-tocopherol in rat liver (IC50 = 0.53 µg/mL versus 0.94 µg/mL), brain (IC50 = 0.10 µg/mL versus 52.52 µg/mL) and plasma (IC50 = 77.17 µg/mL versus 190.81 µg/mL). In the antihepatoma studies, POE showed a greater potency than α-tocopherol in inhibiting Hep G2, Hep 3B and PLC/PRF/5 cells. The antiproliferative effect of POE against these human hepatoma cells was dose-dependent, with IC50 values varying from 4.86 to 68.44 µg/mL. The present results demonstrate that POE is an effective natural antioxidant supplement for protecting cellular membranes against oxidative damage and inhibiting hepatoma cell proliferation.
關聯:	Journal of Food Lipids 14(2)： p.122-137
显示于类别:	[保健營養系(所) ] 期刊論文

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