Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/22223
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 16984/19280 (88%)
造訪人次 : 8626702      線上人數 : 477
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: http://ir.cnu.edu.tw/handle/310902800/22223


    標題: Tetrandrine inhibits proinflammatory cytokines, iNOS and Cox-2 expression in human monocytic cells
    作者: Shu-Jing Wu
    Lean-Teik Ng
    貢獻者: 營養與保健科技研究所
    關鍵字: cytokine
    inducible nitric oxide synthase (iNOS)
    COX-2
    THP-1 cell
    日期: 2007-01
    上傳時間: 2010-01-15 11:13:28 (UTC+8)
    摘要: Tetrandrine (TET), a bis-benzylisoquinoline alkaloid isolated from the dried root of Hang-Fang-Chi (Stephania tetrandra S. MOORE), is traditionally used in China for treating inflammation, hypertension and silicosis. In this study, our aim was to examine the anti-inflammatory mechanism of TET through measuring the inducible nitric oxide synthase (iNOS), cyclooxygenase-1, and -2 (COX-1 and COX-2) expression, cytokines (TNF-α, IL-4 and IL-8) formation, nitric oxide (NO) release and prostaglandin E2 (PGE2) generation in lipopolysaccharide (LPS)-induced human monocytic (THP-1) cells. Results showed that TET remarkably suppressed the LPS (1 μg/ml) induction of NO release and PGE2 generation. It also significantly attenuated the LPS-induced transcription of proinflammatory cytokines (TNF-α, IL-4 and IL-8) in a dose-dependent manner. Furthermore, TET at 100 μM significantly blocked the LPS induction of iNOS and COX-2 expression, but not the COX-1. Taken together, these results suggest that TET exerts anti-inflammatory effects probably through the suppression of COX-2 and iNOS expression.
    顯示於類別:[保健營養系(所) ] 期刊論文

    文件中的檔案:

    檔案 大小格式瀏覽次數
    0KbUnknown590檢視/開啟


    在CNU IR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋