Induction of apoptosis in human breast adenocarcinoma MCF-7 cells by pterocarnin A from the bark of Pterocarya stenoptera via the Fas-mediated pathway.

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Title:	Induction of apoptosis in human breast adenocarcinoma MCF-7 cells by pterocarnin A from the bark of Pterocarya stenoptera via the Fas-mediated pathway.
Authors:	Kuo, Po-Lin Hsu, Ya-Ling Sung, Shu-Chiao Ni, Wen-Chiu Lin, Ta-Chen Lin, Chun-Ching
Contributors:	生物科技系
Date:	2007-06
Issue Date:	2010-01-12 09:13:12 (UTC+8)
Publisher:	Lippincott Williams & Wilkins
Abstract:	Pterocarnin A, isolated from the bark of Pterocarya stenoptera (Juylandaceae), was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. To identify the anticancer mechanism of pterocarnin A, we assayed its effects on apoptosis, cell cycle distribution, and levels of p53, p21/WAF1, Fas/APO-1 receptor and Fas ligand. The results showed that pterocarnin A induced apoptosis of MCF-7 cells without mediation of p53 and p21/WAF1. We suggest that the Fas/Fas ligand apoptotic system is the main pathway of pterocarnin A-mediated apoptosis of MCF-7 cells. Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of pterocarnin A in MCF-7 cells.
Relation:	Anti-Cancer Drugs 18(5)： p.555-562
Appears in Collections:	[Dept. of Biotechnology (including master's program)] Periodical Articles

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