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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/22198


    標題: Inhibition of Low-Density Lipoprotein Oxidation and Oxidative Burst in Polymorphonuclear Neutrophils by Caffeic Acid and Hispidin Derivatives Isolated from Sword Brake Fern (Pteris ensiformis Burm.)
    作者: Hsiu-An Wei
    Tzi-Wei Lian
    Yi-Chen Tu
    Jing-Ting Hong
    Mei-Chun Kou
    Ming-Jiuan Wu
    貢獻者: 生物科技系
    關鍵字: ROS
    oxLDL
    caffeic acid
    hispidin
    oxidative burst
    日期: 2007-11
    上傳時間: 2010-01-12 09:13:01 (UTC+8)
    出版者: Amer Chemical Soc
    摘要: Several antioxidant compounds have been previously identified from sword brake fern (Pteris ensiformis Burm.) by DPPH bleaching and Trolox equivalent antioxidant capacity (TEAC) analyses. Among the isolates, 7-O-caffeoylhydroxymaltol 3-O-β-d-glucopyranoside and hispidin 4-O-β-d-glucopyranoside [6-(3,4-dihydroxystyryl)-4-O-β-d-glucopyranoside-2-pyrone] were two new compounds. The aim of this study is to elucidate the possible effect of the aqueous extract of sword brake fern (SBF) and these two compounds in preventing atherosclerosis. The results demonstrated that SBF and these two compounds strongly inhibited Cu2+-mediated low-density lipoprotein (LDL) oxidation measured by thiobarbituric acid-reactive substances assay (TBARS), conjugated diene production, and relative electrophoretic mobility. The commercial antioxidant dl-α-tocopherol showed lower antioxidant activity than these two compounds at the same molecular concentration. SBF and these two compounds also suppressed N-formylmethionyl-leucylphenylalanine (fMLP)-stimulated reactive oxygen species (ROS) production in human polymorphonuclear neutrophils (PMN). These findings indicate that sword brake fern may prevent atherosclerosis via inhibition of both LDL oxidation and ROS production.
    關聯: Journal of agricultural and food chemistry 55(26): p.10579-10584
    Appears in Collections:[生物科技系(所)] 期刊論文

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