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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/22197


    標題: Immunomodulatory effect of exo-polysaccharides from submerged cultured Cordyceps sinensis: enhancement of cytokine synthesis, CD11b expression, and phagocytosis
    作者: Mei-Chun Kuo
    Chien-Yu Chang
    Tso-Lin Cheng
    Ming-Jiuan Wu
    貢獻者: 生物科技系
    關鍵字: Cordyceps sinensis
    Immunomodulatory effect
    Phagocytosis
    Cytokine
    CD11b
    日期: 2007-06
    上傳時間: 2010-01-12 09:12:59 (UTC+8)
    出版者: Springer
    摘要: Cordyceps sinensis is widely used as a traditional medicine for treatment of a wide variety of diseases or to maintain health. The immunomodulatory activity of polysaccharides prepared from submerged cultured C. sinensis BCRC36421 was investigated in human peripheral blood. Results demonstrated that Fr. A (exo-polysaccharides, 0.025 ∼ 0.1 mg/ml) induced the production of tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, and IL-10 dose-dependently. Fr. A, as low as 0.025 mg/ml, could significantly augment surface expression of CD11b in monocytes and polymorphonuclear neutrophils. Functional assay revealed that Fr. A (0.05 mg/ml) also elevated phagocytosis in monocytes and PMN. On the other hand, Fr. B (intracellular polysaccharides) only moderately induced TNF-α release, CD11b expression, and phagocytosis at the same concentrations. Our results indicate that the immunomodulatory components of submerged cultured C. sinensis mainly reside in the culture filtrate.
    關聯: Applied Microbiology and Biotechnology 75(4): p.769-775
    Appears in Collections:[生物科技系(所)] 期刊論文

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