English  |  正體中文  |  简体中文  |  Items with full text/Total items : 16702/18989 (88%)
Visitors : 5524392      Online Users : 46
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/22060


    標題: The Preparation of Enoxacin-loaded Liposomes and its in Vitro Evaluation in Pig's Eye
    負載Enoxacin 微脂粒之製備及其在體外豬眼睛之評估
    作者: Hung-Hong Lin
    Hui-Mei Yu
    Yi-Hung Tsai
    Li-Ren Hsu
    貢獻者: 藥學系
    關鍵字: Liposomes
    Enoxacin
    Transcorneal
    Pig's eye
    微脂粒
    經眼角膜
    豬眼睛
    日期: 2001
    上傳時間: 2010-03-24 16:45:17 (UTC+8)
    摘要: Varing phospholipids were used to prepare liposomes which were used to perform the evaluation in trascorneal characteristics. Enoxacin was selected as a model drug incorporated in various liposomal formulations as a therapeutic dosage form. Using a combination of the ethanol injection technique and freeze-drying process,the encapsulation efficiency became 9-fold greater than that odtained by using a conventional film method. In the in vitro corneal perfusion studies,enoxacin loaded-liposome was transfered through cornea at aslower rate than free drug. However, enoxacin loaded-liposomes were accumulated primarily in the cornea. The increase in the drug corneal retention for the lipids conformed to the following order:DSPC>DPPC.DMPC. Finally. the DSC analysis was utilized to determine the interaction occuring between liposomes and cornea. The liposomes must be transferred into cornea to alter the constitute of cells and can be prodadly taken up by the cornea via endocytosis.
    關聯: 嘉南學報 27 : p.89-96
    Appears in Collections:[嘉南學報] 27 期 (2001)
    [藥學系(所)] 期刊論文

    Files in This Item:

    There are no files associated with this item.



    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback