Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/21731
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    標題: Norsolorinic acid from Aspergillus nidulans inhibits the proliferation of human breast adenocarcinoma MCF-7 cells via Fas-mediated pathway
    作者: Clay C. C. Wang
    Yi-Ming Chiang
    Po-Lin Kuo
    Jiunn-Kae Chang
    Ya-Ling Hsu
    貢獻者: 藥物科技研究所
    日期: 2008-03
    上傳時間: 2009-10-13 09:29:36 (UTC+8)
    出版者: Wiley
    摘要: Abstract: Norsolorinic acid, isolated from the Aspergillus nidulans, was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. To identity the anticancer mechanism of norsolorinic acid, we assayed its effect on apoptosis, cell cycle distribution, and levels of p53, p21/WAF1, Fas/APO-1 receptor and Fas ligand. The results showed that norsolorinic acid induced apoptosis of MCF-7 cells without mediation of p53 and p21/WAF1. We suggest that Fas/Fas ligand apoptotic system is the main pathway of norsolorinic acid-mediated apoptosis of MCF-7 cells. Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of norsolorinic acid in MCF-7 cells.
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