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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/21727


    標題: Isobolographic analysis of epinephrine with bupivacaine, dextromethorphan, 3-methoxymorphinan, or dextrorphan on infiltrative anesthesia in rats: dose-response studies
    作者: Yu-Wen Chen
    Kuo-Sheng Liu
    Jhi-Joung Wang
    Willy Chou
    Ching-Hsia Hung
    貢獻者: 藥物科技研究所
    關鍵字: Epinephrine
    Cutaneous analgesia
    Bupivacaine
    Dextromethorphan
    3-Methoxymorphinan
    Dextrorphan
    Local anesthetics
    Isobolographic analysis
    日期: 2008-03
    上傳時間: 2009-10-13 09:29:31 (UTC+8)
    出版者: Elsevier
    摘要: Background and Objectives: The aims of this study were to establish the potencies of epinephrine, bupivacaine, dextromethorphan, 3-methoxymorphinan, and dextrorphan and evaluate interactions of epinephrine with bupivacaine, dextromethorphan, 3-methoxymorphinan, or dextrorphan as an infiltrative anesthetic. Bupivacaine, a common and long-acting local anesthetic, was used as control.
    Methods: Dose-dependent responses of epinephrine, dextromethorphan, 3-methoxymorphinan, and dextrorphan on cutaneous analgesia were compared with bupivacaine in rats. The interactions of drugs were evaluated via an isobolographic analysis.
    Results: We found that epinephrine, bupivacaine, dextromethorphan, 3-methoxymorphinan, and dextrorphan produced a dose-dependent local anesthetic effect as infiltrative cutaneous analgesia. Relative potencies were epinephrine > bupivacaine > dextromethorphan > 3-methoxymorphinan > dextrorphan (P < .01 for each comparison). Coadministration of bupivacaine with epinephrine produced a synergistic effect, and coadministration of dextromethorphan, 3-methoxymorphinan, or dextrorphan with epinephrine produced an additive effect.
    Conclusions: Epinephrine, dextromethorphan, 3-methoxymorphinan, and dextrorphan are known to have local anesthetic effects as infiltrative cutaneous analgesia in rats. Epinephrine increased the potency of bupivacaine, but not dextromethorphan, 3-methoxymorphinan, or dextrorphan as an infiltrative anesthetic. The cutaneous analgesic effects of adding epinephrine to dextromethorphan, 3-methoxymorphinan, or dextrorphan, are similar to combinations of 2 local anesthetics.
    關聯: Regional Anesthesia and Pain Medicine 33(2):p.115-121
    Appears in Collections:[藥學系(所)] 期刊論文

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