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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/21589

    標題: Low-dose haloperidol prevents post-operative nausea and vomiting after ambulatory laparoscopic surgery
    作者: T. F. WANG
    Y. H. LIU
    C. C. CHU
    J. P. SHIEH
    J. I. TZENG
    J. J. WANG
    貢獻者: 休閒保健管理系
    關鍵字: Antiemetics
    laparoscopic surgery
    post-operative nausea and vomiting
    日期: 2008-02
    上傳時間: 2009-07-23 10:28:41 (UTC+8)
    摘要: Background: We evaluated the prophylactic effect of low-dose haloperidol (1 mg) on post-operative nausea and vomiting (PONV) in women undergoing ambulatory laparoscopic surgery. Droperidol (0.625 mg) and saline were controls.
    Methods: One hundred and fifty women undergoing ambulatory laparoscopic surgery under general anaesthesia were enrolled in this randomized, double-blind, and placebo-controlled study. After tracheal intubation, the haloperidol group (n=50) received intravenous haloperidol (1 mg), the droperidol group (n=50) received intravenous droperidol (0.625 mg), and the saline group (n=50) received intravenous saline.
    Results: Haloperidol- and droperidol-group patients reported a lower incidence of PONV [24% and 23% vs. 49% (saline group); P<0.05] and requested fewer doses of rescue antiemetics [13% and 16% vs. 38% (saline group); P<0.05] during the first four post-operative hours. During the 24-h post-operative period, haloperidol- and droperidol-group patients also reported a lower incidence of PONV [31% and 32% vs. 62% (saline group); P<0.01]. No differences were found between the haloperidol and droperidol groups.
    Conclusion: Like droperidol (0.625 mg), prophylactic intravenous haloperidol (1 mg) significantly reduced the incidence of PONV in women undergoing ambulatory laparoscopic surgery.
    Appears in Collections:[休閒保健管理系(所)] 期刊論文

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