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    標題: 海巴戟天萃取物清除1,1-Diphenyl-2- picryhyrazyl自由基能力與抑制EBV病毒溶裂循環的效應
    1,1-Diphenyl-2-picryhyrazyl Radical-Scavenging Activity and Inhibitory Effects on the Epstein-Barr Virus Lytic Cycle by Crude Extracts of Morinda citrifolia L
    作者: 林翠品
    陳師瑩
    鄭筑勻
    葉東柏
    Tsuey-Pin Lin
    Shih-Ying Chen
    Chu-Yun Cheng
    Dong-Bor Yeh
    貢獻者: 保健營養系(所)
    生物科技系
    關鍵字: Epstein-Barr病毒
    抗病毒
    海巴戟天
    Epstein-barr virus
    antiviral
    Morinda citrifolia
    日期: 2008-06
    上傳時間: 2009-07-21 14:26:33 (UTC+8)
    摘要: 海巴戟天俗名諾麗(non),在夏威夷與大平洋島嶼被廣泛利用,它有抗腫瘤與抗氧化等活性。本研究之目的將探討海巴戟天各部位水及乙醇粗萃物是否能夠抑制EB病毒溶裂循環,而且也將探討抑制EB病毒溶裂循環的效應與總酣類含量及1,1-Diphenyl-2-Picryrazyl (DPPH)自由基的清除能力是否具有關聯性。結果發現葉乙醇粗萃物比其他部位水及乙醇粗萃物含有較高的總多酚類含量及1,1-Diphenyl-2-Picryrazyl (DPPH)自由基的清除能力。同時也證明這個組萃物在200µg/mL時對EB病毒溶裂循環時期的蛋白質表現具有明顯抑制作用,而且發現葉乙醇粗萃物中多酚類物質可能具有抗氧化及抗病毒的效應。此外,也發現葉乙醇粗萃物明顯抑制作用的濃度對P3HR1細胞不具有毒性,所以具有開發成為抗EB病毒製劑的價值。
    Morinda citrifolia L. (Rubiaceae), commonly known as noni, is used in the Hawaiian and Tahitian islands, and has antitumor and antioxidant activities. The purpose of this study was to investigate whether the crude extracts of M. citrifolia inhibit the lytic cycle of Epstein-Barr virus and the possible relation among antiviral activities, total phenolic contents, and 1,1-diphenyl-2-picryhyrazyl (DPPH) radical-scavenging capacity. We found that the ethanolic extract from leaves of M. citrifolia had the highest Total phenolic contents and DPPH radical-scavenging activity of aqueous and ethanolic extracts. Meanwhile, results demonstrated that 200 �g/mL of this ethanolic extract effectively inhibited the expression of Epstein-Barr virus lytic proteins during the viral lytic cycle, thus showing that the phenolic extract may have antioxidant and antiviral effects. Furthermore, this extract was not toxic toward P3HR1 cells. Thus, it can potentially be developed as an anti-EBV drug.
    Appears in Collections:[保健營養系(所) ] 期刊論文
    [生物科技系(所)] 期刊論文

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